Microneedling vs. Botox: A Comparison for Skin Rejuvenation

May 4, 2023
a white female touching her face with both hands

Botox has long been a leading treatment in aesthetic medicine for reducing visible signs of aging. In recent years, however, other modalities—including dermal fillers, laser resurfacing, and microneedling—have gained recognition for their ability to enhance skin quality and support long-term rejuvenation.

Microneedling, in particular, is increasingly recognized as a minimally invasive procedure that stimulates natural collagen and elastin production, improving overall skin texture and tone. For professionals, understanding how Botox and microneedling differ, and how they may complement one another, is essential when developing treatment plans tailored to client needs.

How does Botox work?

Botox (botulinum toxin type A) functions by temporarily relaxing targeted muscles. When injected, it restricts muscle movement, thereby smoothing dynamic wrinkles caused by repeated facial expressions such as frown lines or crow’s feet.

  • Onset and duration: Visible effects typically appear within several days, lasting approximately 3–6 months before additional injections are required.

  • Treatment experience: Injections are brief and generally well tolerated, though some clients report a stinging sensation, particularly in areas with minimal fatty tissue.

  • Downtime: There is minimal downtime, though mild swelling or bruising at the injection site may occur.

  • Cost considerations: Botox treatments usually range from $300–$1,000 per session, depending on dosage and treatment area, with repeat sessions required for maintenance.

Microneedling, also known as collagen induction therapy, is a controlled procedure performed with a medical-grade device such as the Dr. Pen series. The device creates microscopic punctures in the skin, which trigger the body’s natural healing cascade.

This response stimulates fibroblast activity, leading to the production of new collagen and elastin, while also promoting angiogenesis and increased nutrient delivery to the dermis. The result is firmer, smoother, and more radiant skin over time.

  • Treatment schedule: Microneedling is typically performed once every 4 weeks, allowing the skin to fully remodel between sessions.

  • Longevity of results: Unlike Botox, which wears off, microneedling provides cumulative benefits by strengthening the skin’s structure. Results improve gradually with consistency.

  • Downtime: Clients may experience redness and mild flaking for 24–48 hours, but downtime is minimal.

  • Discomfort: Sensations vary depending on needle depth. Topical anaesthetic can be used to optimize comfort.

  • Cost considerations: In-clinic microneedling sessions typically cost between $200-$800. Advances in technology now also allow safe at-home maintenance with professional-grade devices.

Woman with no facial lines after botox and microneedling touching face

Comparing Botox and Microneedling

Aspect Botox Microneedling
Primary Action Temporarily relaxes targeted muscles to reduce dynamic wrinkles Stimulates collagen and elastin to remodel skin structure
Best For Dynamic wrinkles, prevention of deep expression lines Texture refinement, fine lines, scars, pigmentation, overall rejuvenation
Duration 3–6 months Long-term cumulative results with consistent treatments
Downtime Minimal, possible bruising/swelling 24–48 hours redness, mild peeling
Discomfort Quick stinging sensation at injection site Mild to moderate, reduced with anaesthetic

Can microneedling replace Botox?

Microneedling and Botox serve different functions. Botox prevents and reduces expression-related wrinkles by targeting muscles, while microneedling strengthens the skin itself by stimulating dermal regeneration.

These treatments are not interchangeable but can be highly complementary:

  • Botox reduces dynamic muscle activity.

  • Microneedling restores dermal support with new collagen and elastin.

Together, they can optimize both surface quality and underlying structural support for comprehensive anti-aging results.

Treatment Sequencing: Combining Botox and Microneedling?

If both procedures are being performed:

  • Microneedling before Botox: Wait 3–4 days post-treatment for irritation to subside before injections.

  • Botox before microneedling: Wait at least 2 weeks to allow the toxin to stabilize in the targeted muscles.

This sequencing ensures treatment safety and avoids unwanted migration or reduced efficacy.

Conclusion

Botox and microneedling are two powerful tools in aesthetic practice, each offering unique benefits. Botox is best suited for addressing dynamic wrinkles caused by muscle activity, while microneedling excels in improving skin texture, tone, and resilience through collagen induction.

The decision is not necessarily Botox vs. microneedling—but rather how to strategically combine them to optimize client outcomes. With proper planning, both treatments can play a vital role in comprehensive skin rejuvenation protocols.

For more information on Health Canada–validated Dr. Pen microneedling devices, or to discuss professional treatment integration, contact Dr. Pen Canada’s support team.